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Best Python Web Framework for my API Server Needs

#1
I am working on developing two systems:

1. A system that will constantly retrieve economic data from a 3rd party data feed and push it into a MySQL DB (using sqlalchemy)
2. A server that will allow anyone to query the data in the db over a JSON AJAX API (similar to Yelp or Yahoo API for example)

I have two main questions:

1. Which Python framework should I use in 2)? Pyramid is my first choice, but if you strongly suggest against it or in favor of something else like Django or Pylons I am definitely wiling to consider it.
2. Should I develop the two system separately? Or should 1) be a part of 2), running within the framework (using crontab or celery for example)?

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