Depends on application, really.
Consider setting a timestamp by a user to a server in New York, for an appointment in Sanghai. Now when the user connects in Sanghai, he accesses the same appointment timestamp from a mirrored server in Tokyo. He will see the appointment in Tokyo time, offset from the original New York time.
So for values that represent user time like an appointment or a schedule, datetime is better. It allows the user to control the exact date and time desired, regardless of the server settings. The set time is the set time, not affected by the server's time zone, the user's time zone, or by changes in the way daylight savings time is calculated (yes it does change).
On the other hand, for values that represent system time like payment transactions, table modifications or logging, always use timestamps. The system will not be affected by moving the server to another time zone, or when comparing between servers in different timezones.
Timestamps are also lighter on the database and indexed faster.